The small federal-style building at center dating from the early 19th century may not stand much longer. It is now surrounded by scaffolding, and demolition of the roof has begun. The city has just issued a stop work order, but my guess is that it will only postpone the inevitable. The preservation groups seeking to save the character of the Bowery–this is the northern extension of the Bowery–are admirable, but rather late as you can see by the architectural context. Here is the latest news.
Presumably, the vacant lot at the corner of Third Avenue and E6th Street would be joined with the land under 35 Cooper Square to create a larger site for development.
Cooper Square in 1917
Even in 1917 few of the federal period buildings remained in this part of town.